While this is a trick question. "The answers always Picard."
I'd have to go with Sisko. As *notanothervillain put it, he was the only one to hit Q. Here you have a Captain that gets put, Purposely, at the ass end of the Alpha quadrant. And unlike other Captains that try and tout their "holier that tho" morals. When push comes to shove he tells everyone "to get bent".